Betrixaban
Cat. No.：YN370247
CAS No. ：330942-05-7
| 产品名称: | Betrixaban |
| CAS No.: | 330942-05-7 |
| Chemical Name: | N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide |
| Synonyms: | 贝曲西班; PRT054021 |
| 分子量: | 451.91 |
| 分子式: | C₂₃H₂₂ClN₅O₃ |
| SMILES: | N=C(N(C)C)C(C=C1)=CC=C1C(NC2=CC=C(OC)C=C2C(NC(C=C3)=NC=C3Cl)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Betrixaban (PRT054021) 是一种有效的，具有口服活性的选择性factor Xa(fXa) 抑制剂，IC50为 1.5 nM。 |
| IC50和靶点: | |
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Zhang, P., Huang, W., Wang, L., et al.Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitorBioorg. Med. Chem. Lett.19(8),2179-2185(2009)
Chan, N.C., Bhagirath, V., and Eikelboom, J.W.Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolismVasc. Health Risk Manag.11,343-351(2015)
Cohen, A.T., Harrington, R., Goldhaber, S.Z., et al.The design and rationale for the acute medically Ill venous thromboembolism prevention with extended duration betrixaban (APEX) study167(3),335-341(2014)
