Gabexate mesylate
Cat. No.：YN372791
CAS No. ：56974-61-9
| 产品名称: | Gabexate mesylate |
| CAS No.: | 56974-61-9 |
| Chemical Name: | 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester, monomethanesulfonate |
| Synonyms: | 甲磺酸加贝酯; FOY |
| 分子量: | 417.48 |
| 分子式: | C₁₇H₂₇N₃O₇S |
| SMILES: | O=C(OCC)C1=CC=C(OC(CCCCCNC(N)=N)=O)C=C1.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gabexate 甲磺酸盐是非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。 |
| IC50和靶点: | |
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Ohno, H., Kosaki, G., Kambayashi, J., et al.FOY: [ethyl P-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitroThromb. Res.19(4-5),579-588(1980)
Menegatti, E., Bolognesi, M., Scalia, S., et al.Gabexate mesylate inhibition of serine proteases: Thermodynamic and computer-graphics analysisJ. Pharm. Sci.75(12),1171-1174(1986)
Tamura, Y., Hirado, M., Okamura, K., et al.Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r, and C1 esteraseBiochim. Biophys. Acta484(2),417-422(1977)
Ohno, H., Kambayashi, J., Chang, S.W., et al.FOY: [ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulofibrinolytic system in comparison with heparin or aprotininThromb. Res.24(5-6),445-452(1981)
Yuksel, M., Okajima, K., Uchiba, M., et al.Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytesJ. Pharmacol. Exp. Ther.305(1),298-305(2003)
