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ABT-737

Cat. No.：852808-04-9

  • CAS No. ：852808-04-9

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    • 产品名称: ABT-737
      CAS No.: 852808-04-9
      Chemical Name:
      Synonyms:ABT-737;4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide;ABT 737;4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethyla
      分子量:813.43
      分子式:C₄₂H₄₅ClN₆O₅S₂
      SMILES:CN(CC[C@@H](NC1=CC=C(C=C1[N+]([O-])=O)S(NC(C2=CC=C(C=C2)N3CCN(CC3)CC4=CC=CC=C4C5=CC=C(C=C5)Cl)=O)(=O)=O)CSC6=CC=CC=C6)C
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Ni Chonghaile, T., and Letai, A.Mimicking the BH3 domain to kill cancer cellsOncogene27(Suppl 1),S149-S157(2008)', 'Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., et al.An inhibitor of Bcl-2 family proteins induces regression of solid tumoursNature435(7042),677-681(2005)', 'Bruncko, M., Oost, T.K., Belli, B.A., et al.Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xLJ. Med. Chem.50(4),641-662(2007)', 'Trudel, S., Stewart, A.K., Li, Z., et al.The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalanClin. Cancer Res.13(2),621-629(2007)', 'Konopleva, M., Watt, J., Contractor, R., et al.Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)Cancer Res.68(9),3413-3420(2008)
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