Gambogic Acid

Cat. No.：2752-65-0

CAS No. ：2752-65-0

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5mg

￥751

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10mg

￥1131

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50mg

￥4826

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100mg

￥4826

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200mg

￥4826

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产品名称:	Gambogic Acid
CAS No.:	2752-65-0
Chemical Name:
Synonyms:	藤黄酸; Beta-Guttiferrin
分子量:	628.75
分子式:	C₃₈H₄₄O₈
SMILES:	O=C(O)/C(C)=C\C[C@@]1(C2=O)OC(C)(C)[C@@](C[C@@]2([H])C=C34)([H])[C@]31OC5=C(C(O)=C(C=C[C@](CC/C=C(C)/C)(C)O6)C6=C5C/C=C(C)\C)C4=O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Hoch, D.G., Abegg, D., Hannich, J.T., et al.Combined omics approach identifies gambogic acid and related xanthones as covalent inhibitors of the serine palmitoyltransferase complexCell Chem. Bio.27(5),586-597(2020)', 'Kasibhatla, S., Jessen, K.A., Maliartchouk, S., et al.A role for transferrin receptor in triggering apoptosis when targeted with gambogic acidProc. Natl. Acad. Sci. USA102(34),12095-12100(2005)', 'He, X.y., Liu, X.j., Chen, X., et al.Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cellsBiochem. Biophys. Res. Commun.435(3),397-402(2013)', 'Zhang, H.Z., Kasibhatla, S., Wang, Y., et al.Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assayBioorg. Med. Chem.12(2),309-317(2004)', 'Zhai, D., Jin, C., Shiau, C.W., et al.Gambogic acid is an antagonist of anti-apoptotic Bcl-2-family proteinsMol. Cancer Ther.7(6),1639-1646(2008)', 'Zhao, L., Guo, Q.L., You, Q.D., et al.Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cellsBiol. Pharm. Bull.27(7),998-1003(2004)', "Felth, J., Lesiak-Mieczkowska, K., D'Arcy, P., et al.Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome systemInvest. New Drugs31(3),587-598(2013)", 'Zaks-Makhina, E., Li, H., Grishin, A., et al.Specific and slow inhibition of the Kir2.1 K+ channel by gambogic acidJ. Biol. Chem.284(23),15432-15438(2009)