iKIX1
Cat. No.：YN250359
CAS No. ：656222-54-7
| 产品名称: | iKIX1 |
| CAS No.: | 656222-54-7 |
| Chemical Name: | 2-cyano-acetic acid, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide |
| Synonyms: | iKIX 1;iKIX-1 |
| 分子量: | 303.17 |
| 分子式: | C₁₀H₈Cl₂N₄OS |
| SMILES: | O=C(NNC(NC1=CC=C(Cl)C(Cl)=C1)=S)CC#N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | iKIX1 是一种抗真菌剂 (antifungal agent)，可在体外使耐药的光滑毛囊念珠菌对唑类抗真菌剂重新敏感。iKIX1 抑制介体亚基CgGal11A的 KIX 结构域与CgPdr1的激活结构域之间的相互作用，IC50和Ki分别为 190.2 μM 和 18 μM。iKIX1 用于研究多药耐药性和光滑念珠菌感染。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Nishikawa, J.L., Boeszoermenyi, A., Vale-Silva, L.A., et al.Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interactionNature530(7591),485-489(2016)
