Sordarin sodium
Cat. No.：YN250383
| 产品名称: | Sordarin sodium |
| CAS No.: | 463356-00-5 |
| Chemical Name: | (1R,3aR,4S,4aR,7R,7aR,8aS)-8a-[[(6-deoxy-4-O-methyl-β-D-altropyranosyl)oxy]methyl]-4-formyl-4,4a,5,6,7,7a,8,8a-octahydro-7-methyl-3-(1-methylethyl)-1,4-methano-s-indacene-3a(1H)-carboxylic acid, monosodium salt |
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| 分子量: | 514.58 |
| 分子式: | C₂₇H₃₉NaO₈ |
| SMILES: | O=C([C@]([C@]12C=O)(C(C(C)C)=C[C@H]3C1)[C@@]3(C[C@@]4([H])[C@@]2([H])CC[C@H]4C)CO[C@H](O[C@@H]5C)[C@H]([C@@H]([C@@H]5OC)O)O)O[Na] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sordarin 是一种有效的双苯并酰胺依赖性的eEF2抑制剂，具有抗真菌 (antifungal) 性能。Sordarin 靶向 eEF2，通过阻断 eEF2 介导的 tRNAs 易位来抑制蛋白翻译。Sordarin 对某些真菌(如白色念珠菌、光滑念珠菌和新生念珠菌)具有特异性的翻译抑制作用，而对其他一些真菌(如副假丝酵母菌和卢氏假丝酵母菌)则不能。 |
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Domínguez, J.M., Gómez-Lorenzo, M.G., and Martín, J.J.Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acidJ. Biol. Chem.274(32),22423-22427(1999)
Domínguez, J.M., Kelly, V.A., Kinsman, O.S., et al.Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeastsAntimicrob. Agents Chemother.42(9),2274-2278(1998)
