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Idarubicin hydrochloride

Cat. No.:YN250705

  • CAS No. :57852-57-0

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Idarubicin hydrochloride
      CAS No.: 57852-57-0
      Chemical Name: (7S,9S)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, monohydrochloride
      Synonyms:盐酸伊达比星; 4-Demethoxydaunorubicin hydrochloride
      分子量:533.95
      分子式:C₂₆H₂₈ClNO₉
      SMILES:OC(C(C(C1=CC=CC=C21)=O)=C3C2=O)=C4[C@H](C[C@@](C(C)=O)(O)CC4=C3O)O[C@@](O[C@@H](C)[C@H]5O)([H])C[C@@H]5N.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Idarubicin hydrochloride 是一种蒽环类抗白血病药物。 它抑制拓扑异构酶 II,干扰 DNA 复制和 RNA 转录。Idarubicin hydrochloride 还抑制细菌和酵母菌的生长。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Arcamone, F.Properties of antitumor anthracyclines and new developments in their application: Cain memorial award lectureCancer Res.45(12 Pt 1),5995-5999(1985)

      Dautant, A., d'Estaintot, B.L., Gallois, B., et al.A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 Å resolutionNucleic Acids Res.23(10),1710-1716(1995)

      Binaschi, M., Farinosi, R., Austin, C.A., et al.Human DNA topoisomerase IIα-dependent DNA cleavage and yeast cell killing by anthracycline analoguesCancer Res.58,1886-1892(1998)

      Tallman, M.S., Gilliland, D.G., and Rowe, J.M.Drug therapy for acute myeloid leukemiaBlood106(4),1154-1163(2005)

      Wang, Z.Y., and Chen, Z.Acute promyelocytic leukemia: From highly fatal to highly curableBlood111(5),2505-2515(2008)

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