BAY-876
Cat. No.：YN360003
CAS No. ：1799753-84-6
| 产品名称: | BAY-876 |
| CAS No.: | 1799753-84-6 |
| Chemical Name: | N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide |
| Synonyms: | BAY-876;BAY876;N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide;BAY 876;N4-(1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-7-fluoroquinoline-2,4-dicarboxamide;BCP25065;s8452;S |
| 分子量: | 496.42 |
| 分子式: | C₂₄H₁₆F₄N₆O₂ |
| SMILES: | O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY-876 是一种具有口服活性的，选择性的葡萄糖转运蛋白 1 (GLUT1) 抑制剂，IC50为 2 nM。BAY-876 对GLUT1的选择性是 GLUT2，GLUT3 和 GLUT4 的 130 倍以上。BAY-876 还是一种糖酵解代谢和卵巢癌生长的有效阻滞剂。 |
| IC50和靶点: | [{name:"GLUT1:2 nM (IC50)"},{name: "GLUT2:10.08 μM (IC50)"},{name: "GLUT3:1.67 μM (IC50)"},{name: "GLUT4:0.29 μM (IC50)"}] |
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| Solvent & Solubility: |
Siebeneicher, H., Cleve, A., Rehwinkel, H., et al.Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876ChemMedChem11(20),2261-2271(2016)
