Bitopertin
Cat. No.：YN360199
CAS No. ：845614-11-1
| 产品名称: | Bitopertin |
| CAS No.: | 845614-11-1 |
| Chemical Name: | [4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl][5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]-methanone |
| Synonyms: | 比托派汀; RG1678; RO4917838 |
| 分子量: | 543.46 |
| 分子式: | C₂₁H₂₀F₇N₃O₄S |
| SMILES: | FC1=CC(C(F)(F)F)=CN=C1N2CCN(C(C3=CC(S(=O)(C)=O)=CC=C3O[C@H](C(F)(F)F)C)=O)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bitopertin 是一种有效的非竞争性glycine reuptake抑制剂，抑制甘氨酸摄取，IC50为 25 nM。 |
| IC50和靶点: | |
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Pinard, E., Alanine, A., Alberati, D., et al.Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophreniaJ. Med. Chem.53(12),4603-4614(2010)
Alberati, D., Moreau, J.-L., Lengyel, J., et al.Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophreniaNeuropharmacology62(2),1152-1161(2012)
