Morphothiadin
Cat. No.：YN250173
CAS No. ：1092970-12-1
| 产品名称: | Morphothiadin |
| CAS No.: | 1092970-12-1 |
| Chemical Name: | 4-(2-bromo-4-fluorophenyl)-1,4-dihydro-6-(4-morpholinylmethyl)-2-(2-thiazolyl)-5-pyrimidinecarboxylic acid, ethyl ester |
| Synonyms: | 莫非赛定; GLS4 |
| 分子量: | 509.39 |
| 分子式: | C₂₁H₂₂BrFN₄O₃S |
| SMILES: | O=C(C1=C(CN2CCOCC2)NC(C3=NC=CS3)=NC1C4=CC=C(F)C=C4Br)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Morphothiadin 是野生型和阿德福韦耐药HBV复制的有效抑制剂，其IC50值为 12 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wang, X.-Y., Wei, Z.-M., Wu, G.-Y., et al.In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutationsAntivir. Ther.17(5),793-803(2012)
Wu, G., Liu, B., Zhang, Y., et al.Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assemblyAntimicrob. Agents Chemother.57(11),5344-5354(2013)
