Clevudine
Cat. No.：YN250572
CAS No. ：163252-36-6
| 产品名称: | Clevudine |
| CAS No.: | 163252-36-6 |
| Chemical Name: | 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione |
| Synonyms: | 克拉夫定; L-FMAU |
| 分子量: | 260.22 |
| 分子式: | C₁₀H₁₃FN₂O₅ |
| SMILES: | O=C(C(C)=CN1[C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clevudine (L-FMAU) 是一种非自然L-构型的核苷类似物，具有较强的抗HBV活性，半衰期长，毒性低。Clevudine 是一种非竞争性抑制剂，不与病毒 DNA 结合，而是与聚合酶 (polymerase) 结合。 |
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Painter, G.R., Trost, L.C., Blum, M.R., et al.Clevudine: A novel 1-β-L nucleoside analogue in clinical development for the treatment of HBV infectionFrontiers in Viral Hepatitis,281-300(2003)
Fung, J., Lai, C.-L., Seto, W.-K., et al.Nucleoside/nucleotide analogues in the treatment of chronic hepatitis BJ. Antimicrob. Chemother.66(12),2715-2725(2011)
Chu, C.K., Ma, T., Shanmuganathan, K., et al.Use of 2'-fluoro-5-methyl-β-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virusAntimicrob. Agents Chemother.39(4),979-981(1995)
Aguesse-Germon, S., Liu, S.-H., Chevallier, M., et al.Inhibitory effect of 2'-fluoro-5-methyl-β-L-arabinofuranosyl-uracil on duck hepatitis B virus replicationAntimicrob. Agents Chemother.42(2),369-376(1998)
Peek, S.F., Cote, P.J., Jacob, J.R., et al.Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-β, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax)Hepatology33(1),254-266(2001)
