PSI-6206
Cat. No.：YN250625
CAS No. ：863329-66-2
| 产品名称: | PSI-6206 |
| CAS No.: | 863329-66-2 |
| Chemical Name: | (2'R)-2'-deoxy-2'-fluoro-2'-methyl-uridine |
| Synonyms: | RO 2433; GS-331007 |
| 分子量: | 260.22 |
| 分子式: | C₁₀H₁₃FN₂O₅ |
| SMILES: | O=C(NC1=O)C=CN1[C@H]2[C@](F)([C@@H]([C@H](O2)CO)O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PSI-6206 (RO 2433) 是 PSI-6130 的脱氨衍生物，PSI-6130 是一种有效的选择性 HCV NS5B 聚合酶抑制剂。PSI-6206 低效抑制HCV复制，EC90为 >100 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Murakami, E., Niu, C., Bao, H., et al.The mechanism of action of β-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to β-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymeraseAntimicrob. Agents Chemother.52(2),458-464(2008)
Ma, H., Jiang, W.R., Robledo, N., et al.Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate speciesJ. Biol. Chem.282(41),29812-29820(2007)
