Oxamflatin
Cat. No.：YN290049
CAS No. ：151720-43-3
| 产品名称: | Oxamflatin |
| CAS No.: | 151720-43-3 |
| Chemical Name: | N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-2E-penten-4-ynamide |
| Synonyms: | Metacept-3 |
| 分子量: | 342.37 |
| 分子式: | C₁₇H₁₄N₂O₄S |
| SMILES: | O=C(NO)/C=C/C#CC1=CC=CC(NS(=O)(C2=CC=CC=C2)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oxamflatin (Metacept-3) 是高效的HDAC抑制剂，IC50值为15.7 nM。 |
| IC50和靶点: | [{name:"HDAC:15.7 nM (IC50)"}] |
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| Solvent & Solubility: |
Kim, Y.B., Lee, K.H., Sugita, K., et al.Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylaseOncogene18(15),2461-2470(1999)
Peart, M.J., Tainton, K.M., Ruefli, A.A., et al.Novel mechanisms of apoptosis induced by histone deacetylase inhibitorsCancer Res.63(15),4460-4471(2003)
Dear, A.E., and Medcalf, R.L.The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activityBiochim. Biophys. Acta1492(1),15-22(2000)
