Trichostatin A
Cat. No.：YN290328
CAS No. ：58880-19-6
| 产品名称: | Trichostatin A |
| CAS No.: | 58880-19-6 |
| Chemical Name: | 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide |
| Synonyms: | 曲古抑菌素A; TSA |
| 分子量: | 302.37 |
| 分子式: | C₁₇H₂₂N₂O₃ |
| SMILES: | CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Trichostatin A (TSA) 是有效的，特异的组蛋白去乙酰化酶类型 I 和 II (HDAC class I/II) 抑制剂，对 HDAC 的IC50值为 1.8 nM。 |
| IC50和靶点: | [{name:"HDAC:1.8 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Hoshikawa, Y., Kwon, H.J., Yoshida, M., et al.Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell linesExp. Cell Res.214,189-197(1994)
Taunton, J., Hassig, C.A., and Schreiber, S.L.A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3pScience272(5260),408-411(1996)
