Pimelic Diphenylamide 106
Cat. No.：YN290453
CAS No. ：937039-45-7
| 产品名称: | Pimelic Diphenylamide 106 |
| CAS No.: | 937039-45-7 |
| Chemical Name: | N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide |
| Synonyms: | RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII |
| 分子量: | 339.43 |
| 分子式: | C₂₀H₂₅N₃O₂ |
| SMILES: | O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=C(C)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pimelic Diphenylamide 106 是一种缓慢的, 结合紧密的I类HDAC抑制剂 (抑制HDAC1, 2和3, IC50值分别150 nM, 760nM, 和370 nM), 对II类HDAC没有活性。 |
| IC50和靶点: | [{name:"HDAC1:150 nM (IC50)"},{name: "HDAC3:370 nM (IC50)"},{name: "HDAC2:760 nM (IC50)"},{name: "HDAC8:5000 nM (IC50)"}] |
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| Solvent & Solubility: |
Chou, C.J., Herman, D., and Gottesfeld, J.M.Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylasesJ. Biol. Chem.283(51),35402-35409(2008)
Rai, M., Soragni, E., Jenssen, K., et al.HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse modelPLoS One3(4),(2008)
Herman, D., Jenssen, K., Burnett, R., et al.Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxiaNat. Chem. Biol.2(10),551-558(2006)
Thomas, E.A., Coppola, G., Desplats, P.A., et al.The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic miceProc. Natl. Acad. Sci. USA105(40),15564-15569(2008)
