Tucidinostat
Cat. No.：YN290088
CAS No. ：1616493-44-7
| 产品名称: | Tucidinostat |
| CAS No.: | 1616493-44-7 |
| Chemical Name: | N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide |
| Synonyms: | 西达本胺; Chidamide; HBI-8000; CS 055 |
| 分子量: | 390.41 |
| 分子式: | C₂₂H₁₉FN₄O₂ |
| SMILES: | O=C(C1=CC=C(CNC(/C=C/C2=CN=CC=C2)=O)C=C1)NC(C=CC(F)=C3)=C3N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tucidinostat (Chidamide) 是一种有效的，可口服的HDAC第 I 类HDAC1/2/3和第 IIb 类HDAC10的抑制剂，IC50值分别为 95，160，67 和 78 nM，对 HDAC8 和 HDAC11 的作用较弱 (IC50，733 nM，432 nM)，对 HDAC4/5/6/7/9 无作用。 |
| IC50和靶点: | [{name:"HDAC3:67 nM (IC50)"},{name: "HDAC10:78 nM (IC50)"},{name: "HDAC1:95 nM (IC50)"},{name: "HDAC2:160 nM (IC50)"},{name: "HDAC11:432 nM (IC50)"},{name: "HDAC8:733 nM (IC50)"}] |
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Ning, Z.-Q., Li, Z.-B., Newman, M.J., et al.Chidamide (CS055/HBI-8000): A new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicityCancer Chemother. Pharmacol.69(4),901-909(2012)
Wu, Y., Wang, L., Huang, Y., et al.Nicotinamide phosphoribosyltransferase (NAMPT) is a new target of antitumor agent chidamideACS Med. Chem. Lett.11(1),40-44(2020)
