Abexinostat
Cat. No.：YN290091
CAS No. ：783355-60-2
| 产品名称: | Abexinostat |
| CAS No.: | 783355-60-2 |
| Chemical Name: | 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide |
| Synonyms: | CRA 024781; PCI-24781 |
| 分子量: | 397.42 |
| 分子式: | C₂₁H₂₃N₃O₅ |
| SMILES: | O=C(NCCOC1=CC=C(C=C1)C(NO)=O)C2=C(C3=CC=CC=C3O2)CN(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Abexinostat (CRA 024781) 是一种新的泛HDAC抑制剂，主要靶向HDAC1的Ki值为7 nM。 |
| IC50和靶点: | [{name:"HDAC1:7 nM (Ki)"},{name: "HDAC3/SMRT:8.2 nM (Ki)"},{name: "HDAC6:17 nM (Ki)"},{name: "HDAC2:19 nM (Ki)"},{name: "HDAC10:24 nM (Ki)"},{name: "HDAC8:280 nM (Ki)"},{name: "MBLAC2:<10 nM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Buggy, J.J., Cao, Z.A., Bass, K.E., et al.CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivoMol. Cancer Ther.5(5),1309-1317(2006)
