CCT251236
Cat. No.:YN370120
CAS No. :1693731-40-6
产品名称: | CCT251236 |
CAS No.: | 1693731-40-6 |
Chemical Name: | N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-6-quinolinecarboxamide |
Synonyms: | CCT251236 |
分子量: | 552.62 |
分子式: | C₃₂H₃₂N₄O₅ |
SMILES: | CC1=CC=C(NC(C2=CC(OCCO3)=C3C=C2)=O)C=C1NC(C4=CC(C=CC(OCCN5CCCC5)=N6)=C6C=C4)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | CCT251236是通过热休克转录因子1 (hsf1) 表型筛选得到的有口服活性的吡啶配体,抑制HSF1介导的HSP72诱导的IC50值为19 nM。 |
IC50和靶点: | [{name:"HSP72:19 nM (IC50, SK-OV-3 cells)"}] |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Cheeseman, M.D., Chessum, N.E., Rye, C.S., et al.Discovery of a chemical probe bisamide (CCT251236): An orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screenJ. Med. Chem.60(1),180-201(2017)