Apoptozole
Cat. No.：YN372255
CAS No. ：1054543-47-3
| 产品名称: | Apoptozole |
| CAS No.: | 1054543-47-3 |
| Chemical Name: | 4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl]methyl]-benzamide |
| Synonyms: | Apoptosis Activator VII |
| 分子量: | 625.56 |
| 分子式: | C₃₃H₂₅F₆N₃O₃ |
| SMILES: | NC(C(C=C1)=CC=C1CN2C(C3=CC=C(OC)C=C3)=C(C4=CC=C(OC)C=C4)N=C2C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apoptozole (Apoptosis Activator VII) 是Hsc70和Hsp70的 ATPase 结构域抑制剂，可诱导凋亡，Kd值分别为 0.21 和 0.14 μM。 |
| IC50和靶点: | [{name:"HSP70:0.14 μM (Kd)"},{name: "HSC70:0.21 μM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ko, S.K., Kim, J., Na, D.C., et al.A small molecule inhibitor of ATPase activity of HSP70 iduces apoptosis and has antitumor activitiesChem. Biol.22(3),391-403(2015)
Ljung, B.Vascular selectivity of felodipine: Experimental pharmacologyJ. Cardiovasc. Pharmacol.15(Suppl 4),S11-S16(1990)
