NMS-E973
Cat. No.：YN372454
CAS No. ：1253584-84-7
| 产品名称: | NMS-E973 |
| CAS No.: | 1253584-84-7 |
| Chemical Name: | 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide |
| Synonyms: | NMS-E973; NMSE973; NMS E973. |
| 分子量: | 454.43 |
| 分子式: | C₂₂H₂₂N₄O₇ |
| SMILES: | O=C(C1=NOC(C2=C(OC3=CC=C([N+]([O-])=O)C=C3)C=C(O)C=C2O)=C1)NC4CCN(C)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NMS-E973 是一种有效的，可透过血脑屏障的选择性HSP90抑制剂。NMS-E973 与Hsp90α的 ATP 位点结合，DC50小于 10 nM。NMS-E973 能够穿越血脑屏障 (BBB)。具有抗肿瘤效果。 |
| IC50和靶点: | [{name:"HSP90α:10 nM (DC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Brasca, M.G., Mantegani, S., Amboldi, N., et al.Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)Bioorg. Med. Chem.21(22),7047-7063(2013)
Fogliatto, G., Gianellini, L., Brasca, M.G., et al.NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastasesClin. Cancer Res.19(13),3520-3532(2013)
