SNX-2112
Cat. No.：YN370235
CAS No. ：908112-43-6
| 产品名称: | SNX-2112 |
| CAS No.: | 908112-43-6 |
| Chemical Name: | 2-[(trans-4-hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]-benzamide |
| Synonyms: | PF 04928473 |
| 分子量: | 464.48 |
| 分子式: | C₂₃H₂₇F₃N₄O₃ |
| SMILES: | O=C1CC(C)(C)CC2=C1C(C(F)(F)F)=NN2C3=CC=C(C(N[C@H]4CC[C@@H](CC4)O)=C3)C(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SNX-2112 (PF 04928473) 是一种可口服的Hsp90抑制剂，Kd值为 16 nM，对 Hsp90 α 和 Hsp90β 的IC50值均为 30 nM；同时可诱导 Her-2 的降解, 抑制 Grp94 和 Trap-1 的活性，IC50值分别为 10 nM，4.275 μM 和 0.862 μM。SNX-2112 (PF 04928473) 结合 Hsp90 亚型 Hsp90α, Hsp90β 和 Hsp90b1/Grp94，Kd分别为 4 nM, 6 nM 和 484 nM。 |
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Chandarlapaty, S., Sawai, A., Ye, Q., et al.SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancersClin. Cancer Res.14(1),240-248(2008)
Infante, J.R., Weiss, G.J., Jones, S., et al.Phase I dose-escalation studies of SNX-5422, an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumoursEur. J. Cancer50(17),2897-2904(2014)
