Luminespib
Cat. No.：YN370236
CAS No. ：747412-49-3
| 产品名称: | Luminespib |
| CAS No.: | 747412-49-3 |
| Chemical Name: | 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide |
| Synonyms: | VER-52296; AUY922; NVP-AUY922 |
| 分子量: | 465.54 |
| 分子式: | C₂₆H₃₁N₃O₅ |
| SMILES: | O=C(C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Luminespib (VER-52296) 是有效的HSP90抑制剂，抑制 HSP90α 和 HSP90β 的IC50分别为 7.8 和 21 nM。 |
| IC50和靶点: | [{name:"HSP90α:7.8 nM (IC50)"},{name: "HSP90β:21 nM (IC50)"},{name: "GRP94:535 nM (IC50)"},{name: "TRAP-1:85 nM (IC50)"}] |
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| Solvent & Solubility: |
Brough, P.A., Aherne, W., Barril, X., et al.4,5-diarylisoxazole Hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancerJ. Med. Chem.51(2),196-218(2008)
