Arimoclomol
Cat. No.：YN370333
| 产品名称: | Arimoclomol |
| CAS No.: | 289893-25-0 |
| Chemical Name: | N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidoyl chloride, 1-oxide |
| Synonyms: | BRX-220 free base |
| 分子量: | 313.78 |
| 分子式: | C₁₄H₂₀ClN₃O₃ |
| SMILES: | Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Arimoclomol (BRX-220 free base) 是一种热休克蛋白 (HSP) 的共诱导剂。Arimoclomol 通过增强 Hsp 表达来保护运动神经元，从而通过泛素-蛋白酶体系统直接影响蛋白质聚集及清除错误折叠和装配的蛋白。 |
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Rakonczay, Z., Jr., Iványi, B., Varga, I., et al.Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in ratsFree Radic. Biol. Med.32(12),1283-1292(2002)
Kieran, D., Kalmer, B., Dick, J.R.T., et al.Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS miceNat. Med.10(4),402-405(2004)
