VER-155008
Cat. No.：YN370456
CAS No. ：1134156-31-2
| 产品名称: | VER-155008 |
| CAS No.: | 1134156-31-2 |
| Chemical Name: | 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine |
| Synonyms: | C07 |
| 分子量: | 556.40 |
| 分子式: | C₂₅H₂₃Cl₂N₇O₄ |
| SMILES: | O[C@@H]([C@H]([C@H](N1C(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C1N=CN=C3N)O4)O)[C@H]4COCC5=CC=C(C#N)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VER-155008 是一种Hsp70的抑制剂，对Hsp70，Hsc70 和 Grp7 的IC50值分别为 0.5 μM，2.6 μM 和 2.6 μM，对Hsp70的Kd值为 0.3 μM。 |
| IC50和靶点: | [{name:"HSP70:0.5 μM (IC50)"},{name: "HSC70:2.6 μM (IC50)"},{name: "Grp78:2.6 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Williamson, D.S., Borgognoni, J., Clay, A., et al.Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based designJ. Med. Chem.52(6),1510-1513(2009)
Schlecht, R., Scholz, S.R., Dahmen, H., et al.Functional analysis of Hsp70 inhibitorsPLoS One8(11),(2013)
Macias, A.T., Williamson, D.S., Allen, N., et al.Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivityJ. Med. Chem.54(12),4034-4041(2011)
Massey, A.J., Williamson, D.S., Browne, H., et al.A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cellsCancer Chemother. Pharmacol.66(3),535-545(2015)
Kim, S.H., Kang, J.G., Kim, C.S., et al.The hsp70 inhibitor VER155008 induces paraptosis requiring de novo protein synthesis in anaplastic thyroid carcinoma cellsBiochim. Biophys. Acta454(1),36-41(2014)
