XL888
Cat. No.：YN371381
CAS No. ：1149705-71-4
| 产品名称: | XL888 |
| CAS No.: | 1149705-71-4 |
| Chemical Name: | N1-[(3-endo)-8-[5-(cyclopropylcarbonyl)-2-pyridinyl]-8-azabicyclo[3.2.1]oct-3-yl]-2-methyl-5-[[(1R)-1-methylpropyl]amino]-1,4-benzenedicarboxamide |
| Synonyms: | XL888; XL-888; XL 888 |
| 分子量: | 503.64 |
| 分子式: | C₂₉H₃₇N₅O₃ |
| SMILES: | CC1=CC(C(N)=O)=C(N[C@H](C)CC)C=C1C(N[C@]2([H])C[C@H](CC3)N(C4=NC=C(C(C5CC5)=O)C=C4)[C@H]3C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XL888 是一种热休克蛋白 90 (HSP90) 抑制剂，IC50值为 24 nM。 |
| IC50和靶点: | [{name:"HSP90:24 nM (IC50)"}] |
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| Solvent & Solubility: |
Taldone, T., Sun, W., and Chiosis, G.Discovery and development of heat shock protein 90 inhibitorsBioorg. Med. Chem.17(6),2225-2235(2009)
Bussenius, J., Blazey, C.M., Aay, N., et al.Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90Bioorg. Med. Chem. Lett.22(17),5396-5404(2012)
Lyman, S.K., Crawley, S.C., Gong, R., et al.High-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888PLoS One6(3),1-14(2011)
Haarberg, H.E., Paraiso, K.H.T., Wood, E., et al.Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanomaMol. Cancer Ther.12(6),901-912(2013)
Paraiso, K.H.T., Haarberg, H.E., Wood, E., et al.The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanismsClin. Cancer Res.18(9),2502-2514(2012)
