WM-1119
Cat. No.：YN310054
CAS No. ：2055397-28-7
| 产品名称: | WM-1119 |
| CAS No.: | 2055397-28-7 |
| Chemical Name: | 3-fluoro-5-(2-pyridinyl)-benzoic acid, 2-[(2-fluorophenyl)sulfonyl]hydrazide |
| Synonyms: | WM1119 |
| 分子量: | 389.38 |
| 分子式: | C₁₈H₁₃F₂N₃O₃S |
| SMILES: | O=C(NNS(=O)(C1=CC=CC=C1F)=O)C2=CC(C3=NC=CC=C3)=CC(F)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WM-1119 是强效的、选择性KAT6A抑制剂，淋巴瘤细胞中测得对 KAT6A 的IC50值为 0.25 μM，对 KAT6A，KAT5，KAT7 的结合KD值分别为 2 nM，2.2 μM，0.5 μM。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Priebbenow, D.L., Leaver, D.J., Nguyen, N., et al.Discovery of acylsulfonohydrazide-derived inhibitors of the lysine acetyltransferase, KAT6A, as potent senescence-inducing anti-cancer agentsJ. Med. Chem.63(9),4655-4684(2020)
Baell, J.B., Leaver, D.J., Hermans, S.J., et al.Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growthNature560(7717),253-257(2018)
