Remodelin hydrobromide
Cat. No.：YN310297
CAS No. ：1622921-15-6
| 产品名称: | Remodelin hydrobromide |
| CAS No.: | 1622921-15-6 |
| Chemical Name: | 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, monohydrobromide |
| Synonyms: | Remodelin,Remodelin HBR |
| 分子量: | 363.28 |
| 分子式: | C₁₅H₁₅BrN₄S |
| SMILES: | N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Remodelin 是特异性的 N-乙酰基转移酶NAT10的特异性抑制剂，能改善 Hutchinson-Gilford 早衰综合征细胞表型。Remodelin 通过靶向和抑制 NAT10，在一个不依赖于 progerin 和 FTI 的途径中发挥作用。NAT10 是一种具有组蛋白乙酰化活性的蛋白质，主要参与端粒酶活性的调节。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Larrieu, D., Britton, S., Demir, M., et al.Chemical inhibition of NAT10 corrects defects of laminopathic cellsScience344(6183),527-532(2014)
Chimenti, F., Bizzarri, B., Maccioni, E., et al.Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida sppBioorg. Med. Chem. Lett.17(16),4635-4640(2007)
