RG-12525
Cat. No.：YN320173
CAS No. ：120128-20-3
| 产品名称: | RG-12525 |
| CAS No.: | 120128-20-3 |
| Chemical Name: | |
| Synonyms: | NID 525 |
| 分子量: | 423.47 |
| 分子式: | C₂₅H₂₁N₅O₂ |
| SMILES: | C1(COC2=CC=C(OCC3=CC=CC=C3CC4=NN=NN4)C=C2)=NC5=CC=CC=C5C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RG-12525 是一种特异性的，竞争性的，可口服的LTC4，LTD4和LTE4拮抗剂，能够抑制 LTC4，LTD4 和 LTE4 诱导的豚鼠薄壁带收缩，IC50值分别为 2.6 nM，2.5 nM 和 7 nM；RG-12525 也是PPAR-γ的激动剂，IC50值约为 60 nM，CYP3A4的抑制剂， Ki值为 0.5 µM。 |
| IC50和靶点: | [{name:"PPARγ:60 nM (IC50)"},{name: "CYP3A4:0.5 μM (Ki)"},{name: "LTC4:2.6 nM (IC50, Guinea pig)"},{name: "LTD4:2.5 nM (IC50, Guinea pig)"},{name: "LTE4:7 nM (IC50, Guinea pig)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
