MK-886
Cat. No.：YN320827
CAS No. ：118414-82-7
| 产品名称: | MK-886 |
| CAS No.: | 118414-82-7 |
| Chemical Name: | 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid |
| Synonyms: | L 663536 |
| 分子量: | 472.08 |
| 分子式: | C₂₇H₃₄ClNO₂S |
| SMILES: | CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-886 (L 663536) 是一种有效的，细胞可渗透的且具有口服活性的 FLAP (IC50为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的IC50分别为 3 nM 和 1.1μM) 的抑制剂。MK-886 也是一种非竞争性PPARα拮抗剂，可以诱导细胞凋亡。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dixon, R.A.F., Diehl, R.E., Opas, E., et al.Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesisNature343,282-284(1990)
