GW-803430
Cat. No.：YN320425
CAS No. ：515141-51-2
| 产品名称: | GW-803430 |
| CAS No.: | 515141-51-2 |
| Chemical Name: | 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one |
| Synonyms: | GW-3430 |
| 分子量: | 481.99 |
| 分子式: | C₂₅H₂₄ClN₃O₃S |
| SMILES: | O=C1C2=C(C=C(C3=CC=C(Cl)C=C3)S2)N=CN1C4=CC=C(OCCN5CCCC5)C(OC)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW-803430 (GW-3430) 是一种有效的选择性黑色素浓缩激素受体 1 (MCH R1) 拮抗剂，pIC50为 9.3。GW-803430 在肥胖动物模型中具有口服活性。 |
| IC50和靶点: | |
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Hertzlog, D.L., Al-Barabzanji, K.A., Bigham, E.C., et al.The discovery and optimization of pyrimidinone-containing MCH R1 antagonistsBioorg. Med. Chem. Lett.16(18),4723-4727(2006)
Gehlert, D.R., Rasmussen, K., Shaw, J., et al.Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depressionJ. Pharmacol. Exp. Ther.329(2),429-438(2009)
