MIK665
Cat. No.：YN270113
| 产品名称: | MIK665 |
| CAS No.: | 1799631-75-6 |
| Chemical Name: | αR-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-phenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]-benzenepropanoic acid |
| Synonyms: | S-64315 |
| 分子量: | 875.41 |
| 分子式: | C₄₇H₄₄ClFN₆O₆S |
| SMILES: | OC([C@@H](CC(C=CC=C1)=C1OCC2=CC=NC(C3=CC=CC=C3OC)=N2)OC4=C5[C@]([C@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=C(C8=CC=C(F)C=C8)SC5=NC=N4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MIK665 (S-64315) 是一种特异性的Mcl-1抑制剂，IC50为 1.81 nM，详细信息请参考专利文献 WO2016207225A1 中的化合物 Preparation 13。 |
| IC50和靶点: | [{name:"Mcl-1:1.81 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Du, J., Liu, L., Liu, B., et al.Structure-based virtual screening, biological evaluation and biophysical study of novel Mcl-1 inhibitorsFuture Med. Chem.12(14),1293-1304(2020)
