Reserpine
Cat. No.：YN360932
| 产品名称: | Reserpine |
| CAS No.: | 50-55-5 |
| Chemical Name: | (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester |
| Synonyms: | 利血平 |
| 分子量: | 608.68 |
| 分子式: | C₃₃H₄₀N₂O₉ |
| SMILES: | O=C([C@H]([C@@H](OC)[C@H](OC(C1=CC(OC)=C(OC)C(OC)=C1)=O)C[C@]2([H])CN3CC4)[C@@]2([H])C[C@]3([H])C5=C4C(C=CC(OC)=C6)=C6N5)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Reserpine 是囊泡单胺转运蛋白 2 (VMAT2) 的抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Schuldiner, S., Liu, Y., and Edwards, R.H.Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblastsJ. Biol. Chem.268(1),29-34(1993)
Erickson, J.D., Schäfer, M.K.H., Bonner, T.I., et al.Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporterProc. Natl. Acad. Sci. USA93(10),5166-5171(1996)
Hu, X.T., Wachtel, S.R., Galloway, M.P., et al.Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulationJ. Neurosci.10(7),2318-2329(1990)
Stanwood, G.D., Lucki, I., and McGonigle, P.Differential regulation of dopamine D2 and D3 receptors by chronic drug treatmentsJ. Pharmacol. Exp. Ther.295(3),1232-1240(2000)
Matsumoto, K., Mizowaki, M., Suchitra, T., et al.Central antinociceptive effects of mitragynine in mice: Contribution of descending noradrenergic and serotonergic systemsEur. J. Pharmacol.317(1),75-81(1996)
Wang, E.j., Lew, K., Barecki, M., et al.Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4Chem. Res. Toxicol.14(12),1596-1603(2001)
