BAY-8002
Cat. No.：YN360322
CAS No. ：724440-27-1
| 产品名称: | BAY-8002 |
| CAS No.: | 724440-27-1 |
| Chemical Name: | 2-[[2-chloro-5-(phenylsulfonyl)benzoyl]amino]-benzoic acid |
| Synonyms: | BAY8002,BAY 8002 |
| 分子量: | 415.85 |
| 分子式: | C₂₀H₁₄ClNO₅S |
| SMILES: | O=C(O)C1=CC=CC=C1NC(C2=CC(S(=O)(C3=CC=CC=C3)=O)=CC=C2Cl)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY-8002 是一种有效、选择性、可口服的单羧酸转运蛋白第 1 亚型 (monocarboxylate transporter 1 (MCT1)) 抑制剂，在表达 MCT1 的 DLD-1 细胞中，IC50值为 85 nM，对 MCT1 的选择性远高于 MCT4。具有抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Quanz, M., Bender, E., Kopitz, C., et al.Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistanceMol. Cancer Ther.17(11),2285-2296(2018)
