Rostafuroxin
Cat. No.：YN360328
CAS No. ：156722-18-8
| 产品名称: | Rostafuroxin |
| CAS No.: | 156722-18-8 |
| Chemical Name: | (3β,5β,14β)-21,23-epoxy-24-norchola-20,22-diene-3,14,17-triol |
| Synonyms: | PST 2238 |
| 分子量: | 374.51 |
| 分子式: | C₂₃H₃₄O₄ |
| SMILES: | O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O)C1)C)([H])[C@]2([H])CC3)(CC[C@@]4(C5=COC=C5)O)[C@]34C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rostafuroxin (PST 2238) 是一种洋地黄毒苷衍生物，一种口服有效的Na+,K+-ATPase (ATP1A1)抑制剂。Rostafuroxin 与 ATP1A1 胞外域特异性结合，并阻断呼吸道合胞病毒 (RSV) 触发的 EGFR Tyr845 磷酸化。Rostafuroxin 具有抗高血压和抗 RSV 活性。 |
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Ferrari, P., Ferrandi, M., Valentini, G., et al.Rostafuroxin: An ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertensionAm. J. Physiol. Regul. Integr. Comp. Physiol.290(3),R529-R535(2006)
Ferrari, P., Torielli, L., Ferrandi, M., et al.PST2238: A new antihypertensive compound that antagonizes the long-term pressor effect of ouabainJ. Pharmacol. Exp. Ther.285(1),83-94(1998)
Ferrari, P., Ferrandi, M., Tripodi, G., et al.PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertensionJ. Pharmacol. Exp. Ther.28893,1074-1083(1999)
Staessen, J.A., Thijs, L., Stolarz-Skrzypek, K., et al.Main results of the ouabain and adducin for specific intervention on sodium in hypertension trial (OASIS-HT): A randomized placebo-controlled phase-2 dose-finding study of rostafuroxinTrials12,13(2011)
