Galanthamine

Cat. No.：YN380149

CAS No. ：357-70-0

产品名称:	Galanthamine
CAS No.:	357-70-0
Chemical Name:	(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Synonyms:	加兰他敏; Galantamine
分子量:	287.35
分子式:	C₁₇H₂₁NO₃
SMILES:	O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

Select Batch:

Purity: 98%

产品描述:	Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂，IC50为 500 nM。
IC50和靶点:
In Vitro:
In Vivo:
Clinical Trial:
Solvent & Solubility:

Harvey, A.L.The pharmacology of galanthamine and its analoguesPharmacol. Ther.68(1),113-128(1995)
Rook, Y., Schmidtke, K.U., Gaube, F., et al.Bivalent β-carbolines as potential multitarget anti-Alzheimer agentsJ. Med. Chem.53(9),3611-3617(2010)
Samochocki, M., Zerlin, M., Jostock, R., et al.Galantamine is an allosterically potentiating ligand of the human α4/β2 nAChRActa Neurol. Scand. Suppl.176,68-73(2000)
Van Dam, D., and De Deyn, P.P.Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 modelEur. Neuropsychopharmacol.16(1),59-69(2006)