Mildronate dihydrate
Cat. No.：YN482074
CAS No. ：86426-17-7
| 产品名称: | Mildronate dihydrate |
| CAS No.: | 86426-17-7 |
| Chemical Name: | 2-(2-carboxyethyl)-1,1,1-trimethyl-hydrazinium, inner salt, dihydrate |
| Synonyms: | Meldonium dihydrate; MET-88 dihydrate; Quaterin dihydrate |
| 分子量: | 182.22 |
| 分子式: | C₆H₁₈N₂O₄ |
| SMILES: | C[N+](C)(C)NCCC([O-])=O.O.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mildronate dihydrate (Meldonium dihydrate) 是一种心血管保护药，可竞争性的抑制BBOX1和OCTN2。Mildronate (Meldonium) 对人重组 BBOX 的IC50值为 34-62 μM，对人OCTN2 的EC50值为 21 μM。Mildronate (Meldonium) 可诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。 |
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Makrecka, M., Svalbe, B., Volska, K., et al.Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenationEur. J. Pharmacol.723,55-61(2014)
Klusa, V., Beitnere, U., Pupure, J., et al.Mildronate and its neuroregulatory mechanisms: Targeting the mitochondria, neuroinflammation, and protein expressionMedicina (Kaunas)49(7),301-309(2013)
Beitnere, U., van Groen, T., Kumar, A., et al.Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease miceJ. Neurosci. Res.92(3),338-346(2014)
