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Lucigenin

Cat. No.:YN482221

  • CAS No. :2315-97-1

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    • 参考文献
    • 产品名称: Lucigenin
      CAS No.: 2315-97-1
      Chemical Name: 10,10'-dimethyl-9,9'-biacridinium, dinitrate
      Synonyms:光泽精; NSC-151912; L-6868
      分子量:510.50
      分子式:C₂₈H₂₂N₄O₆
      SMILES:C[N+]1=C2C=CC=CC2=C(C3=C4C=CC=CC4=[N+](C)C5=C3C=CC=C5)C6=C1C=CC=C6.O=N([O-])=O.O=N([O-])=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Lucigenin(L-6868; NSC-151912)是一种化学发光探针用于检测内源性产生的超氧阴离子自由基在细胞的存在。
      IC50和靶点:
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      In Vivo:
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    • Li, Y., Zhu, H., Kuppusamy, P., et al.Validation of lucigenin (Bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systemsJ. Biol. Chem.273(4),2015-2023(1998)

      Biwersi, J., Tulk, B., and Werkman, A.S.Long-wavelength chloride-sensitive fluorescent indicatorsAnal. Biochem.219(1),139-143(1994)

      Vladimirov, Y.A., and Proskurnina, E.V.Free radicals and cell chemiluminescenceBiochemistry (Mosc.)74(13),1545-1566(2009)

      Skatchkov, M.P., Sperling, D., Hink, U., et al.Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide productionBiochem. Biophys. Res. Commun.254(2),319-324(1999)

      Cai, H., Dikalov, S., Griendling, K.K., et al.Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: Comparison of sensitivity and specificityMethods Mol. Med.139,293-311(2007)

      Rezende, F., Löwe, O., Helfinger, V., et al.Unchanged NADPH oxidase activity in Nox1-Nox2-Nox4 triple knockout mice – What do NADPH-stimulated chemiluminescence assays really detect?Antioxid. Redox Signal.24(7),392-399(2016)

      Bunting, J.P., and Gray, D.A.Development of a flow injection chemiluminescent assay for the quantification of lipid hydroperoxidesJ. Am. Oil Chem. Soc.80(10),951-955(2003)

      Ferdani, R., Li, R., Pajewski, R., et al.Transport of chloride and carboxyfluorescein through phospholipid vesicle membranes by heptapeptide amphiphilesOrg. Biomol. Chem.5(15),2423-2432(2007)

      Ruedas-Rama, M.J., Orte, A., Hall, E.A.H., et al.A chloride ion nanosensor for time-resolved fluorimetry and fluorescence lifetime imagingAnalyst137(6),1500-1508(2012)

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