Avicularin

Cat. No.：YN482390

CAS No. ：572-30-5

产品名称:	Avicularin
CAS No.:	572-30-5
Chemical Name:	3-(α-L-arabinofuranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Synonyms:	Fenicularin,扁蓄苷
分子量:	434.35
分子式:	C₂₀H₁₈O₁₁
SMILES:	O=C1C(O[C@H]2[C@@H]([C@H]([C@H](CO)O2)O)O)=C(C3=CC=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 98%

产品描述:	Avicularin 是一种存在多种植物中有生物活性的黄酮类化合物，具有抗炎、抗过敏、抗氧化、保肝、抗肿瘤等作用。在 LPS 刺激的 RAW 264.7 巨噬细胞中，Avicularin 通过抑制 ERK 信号通路产生抗炎活性。Avicularin 能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。
IC50和靶点:
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Abramson, H.N.The lipogenesis pathway as a cancer targetJ. Med. Chem.54(16),5615-5638(2011)
Naeem, S., Hylands, P., and Barlow, D.Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductaseBioorg. Med. Chem.20(3),1251-1258(2012)
Zhang, X., Thuong, P.T., Jin, W., et al.Antioxidant activity of anthraquinones and flavonoids from flower of Reynoutria sachalinensisArch. Pharm. Res.28(1),22-27(2005)
Vo, V.A., Lee, J.-W., Chang, J.-E., et al.Avicularin inhibits lipopolysaccharide-induced inflammatory response by suppressing ERK phosphorylation in RAW 264.7 macrophagesBiomol. Ther. (Seoul)20(6),532-537(2012)
Wang, Z., Li, F., Quan, Y., et al.Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activitiesMol. Med. Rep.19(6),5417-5423(2019)