Dehydrocostus Lactone
Cat. No.：YN482497
CAS No. ：477-43-0
| 产品名称: | Dehydrocostus Lactone |
| CAS No.: | 477-43-0 |
| Chemical Name: | (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one |
| Synonyms: | 去氢木香烃内酯; (-)-Dehydrocostus lactone; Epiligulyl oxide |
| 分子量: | 230.30 |
| 分子式: | C₁₅H₁₈O₂ |
| SMILES: | O=C(O[C@@]([C@@]1([H])C(CC[C@@]21[H])=C)([H])[C@@]3([H])CCC2=C)C3=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dehydrocostus Lactone 是从云木香中分离到的一类主要的倍半萜内酯。 |
| IC50和靶点: | |
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Pandey, M.M., Rastogi, S., and Rawat, A.K.Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plantJ. Ethnopharmacol.110(3),379-390(2007)
Wang, C.Y., Tsai, A.C., Peng, C.Y., et al.Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathwaysPLoS One7(2),(2012)
Lohberger, B., Rinner, B., Stuendl, N., et al.Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cellsPLoS One8(6),e66300(2013)
Li, X., Peng, Z., and Su, C.Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactoneInt. J. Mol. Sci.16(5),10888-10906(2015)
Butturini, E., Cavalieri, E., Carcereri de Prati, A., et al.Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activationPLoS One6(5),e20174(2011)
Scarponi, C., Butturini, E., Sestito, R., et al.Inhibition of inflammatory and proliferative responses of human keratinocytes exposed to the sesquiterpene lactones dehydrocostuslactone and costunolidePLoS One9(9),(2014)
