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Veratramine

Cat. No.:YN482568

  • CAS No. :60-70-8

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    • 参考文献
    • 产品名称: Veratramine
      CAS No.: 60-70-8
      Chemical Name: 5S-methyl-2S-[1S-[2,3S,4,6,6aR,11,11aS,11bR-octahydro-3R-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-3-piperidinol
      Synonyms:黎芦碱; NSC17821; NSC23880
      分子量:409.60
      分子式:C₂₇H₃₉NO₂
      SMILES:O[C@H]1[C@H]([C@H](C2=C(C)C3=C(C=C2)[C@]4([H])CC=C(C[C@@H](O)CC5)[C@@]5(C)[C@@]4([H])C3)C)NC[C@@H](C)C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Veratramine(NSC17821; NSC23880)是信号转导抑制剂,可作用于肿瘤。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Heretsch, P., Tzagkaroulaki, L., and Giannis, A.Cyclopamine and hedgehog signaling: Chemistry, biology, medical perspectivesAgnew. Chem. Int. Ed. Engl.49(20),3418-3427(2010)

      Xu, F.G., Ma, Q.Y., and Wang, Z.Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancerCancer Lett.283(2),119-124(2009)

      Mahindroo, N., Punchihewa, C., and Fujii, N.Hedgehog-Gli signaling pathway inhibitors as anticancer agentsJ. Med. Chem.52(13),3829-3845(2009)

      Tang, J., Li, H.L., Shen, Y.H., et al.Antitumor and antiplatelet activity of alkaloids from Veratrum dahuricumPhytother. Res.24(6),821-826(2010)

      Nagata, R., Izumi, K., Iwata, S.i., et al.Mechanisms of veratramine-induced 5-HT syndrome in miceJpn. J. Pharmacol.55,139-146(1991)

      Fukuma, K.Actions of veratramine on the central nervous systemJpn. J. Pharmacol.5,102-114(1956)

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