Bruceantin
Cat. No.：YN482570
| 产品名称: | Bruceantin |
| CAS No.: | 41451-75-6 |
| Chemical Name: | (11β,12α,15β)-15-[[(2E)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-picras-3-en-21-oic acid, methyl ester |
| Synonyms: | 鸦胆亭; (-) |
| 分子量: | 548.58 |
| 分子式: | C₂₈H₃₆O₁₁ |
| SMILES: | O=C([C@@]1([C@H]([C@H](O)[C@]2([H])[C@]3(C4)C)O)[C@@]([C@H](C5=O)OC(/C=C(C)/C(C)C)=O)([H])[C@@]2([C@@](O5)([H])C[C@@]3([H])C(C)=C(O)C4=O)CO1)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bruceantin(NSC165563)可从痢鸦胆子中提取，对B16黑色素瘤，结肠癌38，L1210和白血病P388有抑制性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Liao, L.L., Kupchan, S.M., and Horwitz, S.B.Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesisMol. Pharmacol.12(1),167-176(1976)
Ekong, R.M., Kirby, G.C., Patel, G., et al.Comparison of the in vitro activities of quassinoids with activity against Plasmodium falciparum, anisomycin and some other inhibitors of eukaryotic protein synthesisBiochem. Pharmacol.40(2),297-301(1990)
Cuendet, M., and Pezzuto, J.M.Antitumor activity of bruceantin: An old drug with new promiseJ. Nat. Prod.67(2),269-272(2004)
