Micheliolide
Cat. No.：YN482572
| 产品名称: | Micheliolide |
| CAS No.: | 68370-47-8 |
| Chemical Name: | 3aS,4,5,7,8,9R,9aS,9bS-octahydro-9-hydroxy-6,9-dimethyl-3-methylene-azuleno[4,5-b]furan-2(3H)-one |
| Synonyms: | 木香内酯 |
| 分子量: | 248.32 |
| 分子式: | C₁₅H₂₀O₃ |
| SMILES: | O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3CC[C@@](C)(O)[C@@]31[H])C2=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Micheliolide能减弱高糖刺激的NF-κB活化，IκBα的降解，和MCP-1，TGF-β1，FN在鼠系膜细胞的表达。 |
| IC50和靶点: | |
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Li, J., Li, S., Guo, J., et al.Natural product micheliolide (MCL) irreversibly activates pyruvate kinase M2 and suppresses leukemiaJ. Med. Chem.61(9),4155-4164(2018)
Zhang, Q., Jiang, X., He, W., et al.MCL plays an anti-inflammatory role in Mycobacterium tuberculosis-induced immune response by inhibiting NF-κB and NLRP3 inflammasome activationMediators Inflamm.,2432904(2017)
Xu, H., Wang, J., Wang, C., et al.Therapeutic effects of micheliolide on a murine model of rheumatoid arthritisMol. Med. Rep.11(1),489-493(2015)
Zhong, J., Gong, W., Chen, J., et al.Micheliolide alleviates hepatic steatosis in db/db mice by inhibiting inflammation and promoting autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR signalingInt. Immunopharmacol.59,197-208(2018)
