Arenobufagin
Cat. No.：YN482593
CAS No. ：464-74-4
| 产品名称: | Arenobufagin |
| CAS No.: | 464-74-4 |
| Chemical Name: | (3β,5β,11α)-3,11,14-trihydroxy-12-oxo-bufa-20,22-dienolide |
| Synonyms: | 沙蟾毒精 |
| 分子量: | 416.51 |
| 分子式: | C₂₄H₃₂O₆ |
| SMILES: | C[C@]([C@@H](C(C=C1)=COC1=O)CC2)(C3=O)[C@]2([C@@](CC[C@@]4([H])[C@@]5(CC[C@H](O)C4)C)([H])[C@]5([H])[C@@H]3O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Arenobufagin 是由蟾蜍毒液提取的蟾蜍甾烯，具有抗癌活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
dos Santos Cruz, J., and Matsuda, H.Arenobufagin, a compound in toad venom, blocks Na+-K+ pump current in cardiac myocytesEur. J. Pharmacol.239(1-3),223-226(1993)
Zhang, D.-M., Liu, J.-S., Deng, L.-J., et al.Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/ mTOR pathwayCarcinogenesis34(6),1331-1342(2013)
Chen, L., Mai, W., Chen, M., et al.Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-cateninPharmacol. Res.123,130-142(2017)
Li, M.W., S., Liu, Z., Zhang, W., et al.Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathwayBiochem. Pharmacol.83(9),1251-1260(2012)
