Koumine
Cat. No.：YN482674
| 产品名称: | Koumine |
| CAS No.: | 1358-76-5 |
| Chemical Name: | (3S,4S,4aR,6R,11bS,11cS)-11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4-(epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole |
| Synonyms: | 钩吻素子 |
| 分子量: | 306.40 |
| 分子式: | C₂₀H₂₂N₂O |
| SMILES: | C=C[C@]12[C@]3([H])C[C@@H]4C5=NC6=CC=CC=C6[C@@]51C[C@H](N(C)C2)[C@@]3([H])CO4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Koumine 是从钩吻 (Gelsemium elegans) 中得到的生物碱，具有高效抗肿瘤活性，在肿瘤细胞中能够增加 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。Koumine 具有抗焦虑、抗应激、抗银屑病和镇痛活性。在类风湿性关节炎动物模型中，Koumine 能够预防关节炎的发展。 |
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Zhang, X., Chen, Y., Gao, B., et al.Apoptotic effect of koumine on human breast cancer cells and the mechanism involvedCell Biochem. Biophys.72(2),411-416(2015)
Yuan, Z., Matias, F.B., Wu, J., et al.Koumine attenuates lipopolysaccaride-stimulated inflammation in RAW264.7 macrophages, coincidentally associated with inhibition of NF-κB, ERK and p38 pathwaysInt. J. Mol. Sci.17(3),430(2016)
Liu, M., Huang, H.-H., Yang, J., et al.The active alkaloids of Gelsemium elegans Benth. are potent anxiolyticsPsychopharmacology (Berl)225(4),839-851(2013)
Xu, Y., Qiu, H.-Q., Liu, H., et al.Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolonePharmacol. Biochem. Behav.101(3),504-514(2012)
