Demethylwedelolactone
Cat. No.：YN482752
| 产品名称: | Demethylwedelolactone |
| CAS No.: | 6468-55-9 |
| Chemical Name: | 1,3,8,9-tetrahydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one |
| Synonyms: | 去甲蟛蜞菊内酯 |
| 分子量: | 300.22 |
| 分子式: | C₁₅H₈O₇ |
| SMILES: | O=C1C2=C(OC3=CC(O)=C(O)C=C32)C4=C(O)C=C(O)C=C4O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Demethylwedelolactone 是一种天然存在的 coumestan，从Eclipta alba中分离得到。Demethylwedelolactone 是一种有效的trypsin抑制剂，其IC50值为 3.0 μM。Demethylwedelolactone 能抑制乳腺癌细胞的移动和侵袭。 |
| IC50和靶点: | |
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Wagner, H., Geyer, B., Kiso, Y., et al.Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulaceaPlanta Med.5,370-374(1986)
Syed, S.D., Deepak, M., Yogisha, S., et al.Trypsin inhibitory effect of wedelolactone and demethylwedelolactonePhytother. Res.17(4),420-421(2003)
Pithayanukul, P., Laovachirasuwan, S., Bavovada, R., et al.Anti-venom potential of butanolic extract of Eclipta prostrata against Malayan pit viper venomJ. Ethnaopharmacol.90(2-3),347-352(2004)
Lee, Y.-J., Lin, W.-L., Chen, N.-F., et al.Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude miceEur. J. Med. Chem.56(1),631-637(2012)
