Periplogenin
Cat. No.：YN482912
CAS No. ：514-39-6
| 产品名称: | Periplogenin |
| CAS No.: | 514-39-6 |
| Chemical Name: | 3β,5β,14-trihydroxy-card-20(22)-enolide |
| Synonyms: | 杠柳苷元 |
| 分子量: | 390.51 |
| 分子式: | C₂₃H₃₄O₅ |
| SMILES: | O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C4=CC(OC4)=O)CC2)C)([H])[C@@]5([C@@](O)(C[C@@H](O)CC5)CC3)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Periplogenin 是白芷根中存在的天然呋喃香豆素，具有高效的抗银屑病作用。Periplogenin 能诱导脂肪细胞分化。 |
| IC50和靶点: | |
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Bloise, E., Braca, A., De Tommasi, N., et al.Pro-apoptotic and cytostatic activity of naturally occurring cardenolidesCancer Chemother. Pharmacol.64(4),793-802(2009)
He, J., Bo, F., Tu, Y., et al.A validated LC-MS/MS assay for the simultaneous determination of periplocin and its two metabolites, periplocymarin and periplogenin in rat plasma: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.114,292-295(2015)
Zhang, W.-J., Song, Z.-B., Bao, Y.-L., et al.Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse modelsBiochem. Pharmacol.105,66-79(2016)
