Senecionine
Cat. No.：YN482955
CAS No. ：130-01-8
| 产品名称: | Senecionine |
| CAS No.: | 130-01-8 |
| Chemical Name: | (3Z,5R,6R,14aR,14bR)-3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione |
| Synonyms: | Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin |
| 分子量: | 335.39 |
| 分子式: | C₁₈H₂₅NO₅ |
| SMILES: | O=C1O[C@@]2([H])[C@]3([H])N(CC=C3COC([C@](C)(O)[C@H](C)C/C1=C/C)=O)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Senecionine (Senecionan-11,16-dione, 12-hydroxy-) 是一种从Senecio vulgaris中分离出来的吡咯里西啶生物碱。 Senecionine对动物和人类有毒。 |
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Xiong, A., Yang, F., Fang, L., et al.Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloidChem. Res. Toxicol.27(5),775-786(2014)
Yang, X., Wang, H., Ni, H.-M., et al.Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in miceRedox Biol.12,264-273(2017)
Miranda, C.L., Reed, R.L., Guengerich, F.P., et al.Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liverCarcinogenesis12(3),515-519(1991)
