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Heraclenin

Cat. No.:YN483075

  • CAS No. :2880-49-1

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    • 生物活性
    • 参考文献
    • 产品名称: Heraclenin
      CAS No.: 2880-49-1
      Chemical Name: 9-[[(2R)-3,3-Dimethyl-2-oxiranyl]methoxy]-7H-furo[3,2-g][1]benzopyran-7-one; (+)-Heraclenin; Prangenin; 9-[[(2R)-3,3-Dimethyloxiranyl]methoxy]-7H-furo[3,2-g][1]benzopyran-7-one; (R)-(+)-9-(2,3-Epoxy-3-methylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
      Synonyms:独活内酯
      分子量:286.28
      分子式:C₁₆H₁₄O₅
      SMILES:CC1(C)[C@H](O1)COC2=C(OC=C3)C3=CC(C=C4)=C2OC4=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Heraclenin,是一种天然呋喃香豆素,可从Prangos pabularia根部分离出来。Heraclenin 通过靶向激活的 T 细胞核因子 (NFAT) 来抑制人原代 T 细胞中 T 细胞受体介导的增殖,这种作用存在浓度依赖性。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • 1. Schimmer, O., et al., . Mutagenicity of a furocoumarin epoxide, heraclenin, in Chlamydomonas reinhardii. Mutation research. 169(1-2): 47-50. PMID: 39452362. Abel, G., et al., . Chromosome-damaging effects of heraclenin in human lymphocytes in vitro. Mutation research. 169(1-2): 51-4. PMID: 39452373. Mishra, K C., et al., 1969. Anticoagulant activity of Heraclenin. Indian journal of physiology and pharmacology. 13(3): 153-5. PMID: 53626304. Appendino, Giovanni., et al., 2004. Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin. Journal of natural products. 67(4): 532-6. PMID: 15104479

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