14-Deoxyandrographolide
Cat. No.：YN483210
| 产品名称: | 14-Deoxyandrographolide |
| CAS No.: | 4176-97-0 |
| Chemical Name: | 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone |
| Synonyms: | 14-去氧穿心莲内酯 |
| 分子量: | 334.45 |
| 分子式: | C₂₀H₃₀O₄ |
| SMILES: | O=C1OCC=C1CC[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 14-Deoxyandrographolide 是Andrographis paniculata的生物活性成分，具有保护肝脏的作用。14-Deoxyandrographolide 通过诱导 TNFRSF1A 的释放，逐渐使肝细胞对 TNF-α 介导的凋亡脱敏。 |
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Chen, L., Zhu, H., Wang, R., et al.ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculataJ. Nat. Prod.71(5),852-855(2008)
Tan, M.L., Kuroyanagi, M., Sulaiman, S.F., et al.Cytotoxic Activities of Major Diterpenoid Constituents of Andrographis paniculata. in a Panel of Human Tumor Cell LinesPharmaceutical Biology43(6),501-508(2008)
Mandal, S., Nelson, V.K., Mukhopadhyay, S., et al.14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in ratsFood. Chem. Toxicol.59,236-248(2013)
Arha, D., Pandeti, S., Mishra, A., et al.Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivoEur. J. Pharmacol.768,207-216(2015)
