Tryptanthrin
Cat. No.：YN483320
| 产品名称: | Tryptanthrin |
| CAS No.: | 13220-57-0 |
| Chemical Name: | indolo[2,1-b]quinazoline-6,12-dione |
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| 分子量: | 248.24 |
| 分子式: | C₁₅H₈N₂O₂ |
| SMILES: | O=C1C2=CC=CC=C2N3C(C4=CC=CC=C4N=C13)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tryptanthrin 是一种有效的口服活性细胞内Leukotriene (LT) biosynthesis抑制剂。 Tryptanthrin 抑制人全血中Leukotriene 的形成 (IC50= 10 µM)，并降低大鼠胸膜炎模型中的 LTB4 水平。 |
| IC50和靶点: | |
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Pergola, C., Jazzar, B., Rossi, A., et al.On the inhibition of 5-lipoxygenase product formation by tryptanthrin: Mechanistic studies and efficacy in vivoBr. J. Pharmacol.165(3),765-776(2012)
Danz, H., Stoyanova, S., Wippich, P., et al.Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoriaPlanta Med.67(5),411-416(2001)
Liao, X., Zhou, X., Mak, N.K., et al.Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathwayPLoS One8(12),(2013)
Moon, S.Y., Lee, J.H., Choi, H.Y., et al.Tryptanthrin protects hepatocytes against oxidative stress via activation of the extracellular signal-regulated kinase/NF-E2-related factor 2 pathwayBiol. Pharm. Bull.37(10),1633-1640(2014)
